Reversal of acute rejection episodes by deoxyspergualin (NKT-01) in dogs receiving renal allografts.
نویسندگان
چکیده
the preventive effect of NKT-01on the rejection of renal allografts in dogs, and suggested that NKT-01 maybe useful in clinical organ transplantation.70 In this study we have explored the efficacy of NKT-01 in treating acute rejection episodes in dogs receiving renal allografts. Unrelated outbred beagle dogs were used for the experiment. Renal allografting was performed as previously described.8»9) Briefly, grafted kidneys were placed in the iliac fossa
منابع مشابه
THE ROLE OF T-L YMPHOCYTE SUBPOPULATION IN RENAL ALLOGRAFT REJECTION
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The mode of in vivo cell-killing by 15-deoxyspergualin (NKT-01) was assessed by measuring change of whole body radioactivity of mice inoculated with 125I-iododeoxyuridine-labeled P388 leukemia cells. Although NKT-01 showed strong life prolonging effect on P388 leukemia-bearing mice, significant excretion of 125I was not observed within 4 days after the start of treatment with NKT-01. Thereafter...
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 41 10 شماره
صفحات -
تاریخ انتشار 1988